Inflammasome-driven inflammation extends into the extracellular space and to neighboring cells through the passive release of specks consisting of the adaptor ASC; this perpetuates the innate immune response and adds a dimension beyond interleukin 1 to autoinflammation.
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H.M.H. is a consultant for SOBI, Novartis and Regeneron.
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Broderick, L., Hoffman, H. cASCading specks. Nat Immunol 15, 698–700 (2014). https://doi.org/10.1038/ni.2942
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DOI: https://doi.org/10.1038/ni.2942