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Countering inflammatory signals in obesity

Although it is generally considered a proinflammatory cytokine, interleukin 6 (IL-6) has anti-inflammatory effects in macrophages by sensitizing them to IL-4 through upregulation of the IL-4 receptor.

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Figure 1: The paradoxical role of IL-6 in regulating metabolic homeostasis.

Katie Vicari

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Correspondence to Shannon M Reilly.

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Reilly, S., Saltiel, A. Countering inflammatory signals in obesity. Nat Immunol 15, 410–411 (2014). https://doi.org/10.1038/ni.2874

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