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A Tip leads cytotoxic T cells to the crime scene in neuroinflammation

Nature Immunology volume 14, pages 196–197 (2013)Cite this article

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By increasing the range of epitopes presented to lymphocytes, determinant spreading allows a more diverse response to ensue. Now the cellular culprits responsible for determinant spreading in the central nervous system have been identified: they are specialized dendritic cells that recruit CD8+ T cells to an autoimmune 'crime'.

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Figure 1: Naive CD8+ T cells with receptors for myelin proteins can be activated by Tip-DCs in the brain, after EAE is induced with CD4+ T cells.

Marina Corral

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Authors and Affiliations

  1. Lawrence Steinman is in the Department of Neurology, the Department Neurological Sciences and the Interdepartmental Program in Immunology, Stanford University, Stanford, California, USA.,

    Lawrence Steinman

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  1. Lawrence Steinman
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Correspondence to Lawrence Steinman.

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The author declares no competing financial interests.

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Steinman, L. A Tip leads cytotoxic T cells to the crime scene in neuroinflammation. Nat Immunol 14, 196–197 (2013). https://doi.org/10.1038/ni.2551

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