The Nr4a family of transcription factors transactivate expression of the transcription factor Foxp3 and are essential for the generation of regulatory T cells. Mice deficient in all three members of the Nr4a family develop massive multiorgan inflammation.
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Bandukwala, H., Rao, A. 'Nurr'ishing Treg cells: Nr4a transcription factors control Foxp3 expression. Nat Immunol 14, 201–203 (2013). https://doi.org/10.1038/ni.2546
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DOI: https://doi.org/10.1038/ni.2546
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