Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

'Nurr'ishing Treg cells: Nr4a transcription factors control Foxp3 expression

The Nr4a family of transcription factors transactivate expression of the transcription factor Foxp3 and are essential for the generation of regulatory T cells. Mice deficient in all three members of the Nr4a family develop massive multiorgan inflammation.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Pleiotropic roles of Nr4a transcription factors in limiting autoimmunity.

References

  1. Ziegler, S. Annu. Rev. Immunol. 24, 209–226 (2006).

    Article  CAS  Google Scholar 

  2. Josefowicz, S.Z., Lu, L.-F. & Rudensky, A.Y. Annu. Rev. Immunol. 30, 531–564 (2012).

    Article  CAS  Google Scholar 

  3. Sekiya, M. et al. Nat. Immunol. 14, 230–237 (2013).

    Article  CAS  Google Scholar 

  4. Lyon, M.F., Peters, J., Glenister, P.H., Ball, S. & Wright, E. Proc. Natl. Acad. Sci. USA 87, 2433–2437 (1990).

    Article  CAS  Google Scholar 

  5. Godfrey, V.L., Wilkinson, J.E. & Russell, L.B. Am. J. Pathol. 138, 1379–1387 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Sekiya, T. et al. Nat. Commun. 2, 269 (2011).

    Article  Google Scholar 

  7. Moran, A.E. et al. J. Exp. Med. 208, 1279–1289 (2011).

    Article  CAS  Google Scholar 

  8. Cheng, L.E., Chan, F.K., Cado, D. & Winoto, A. EMBO J. 16, 1865–1875 (1997).

    Article  CAS  Google Scholar 

  9. Zhou, T. et al. J. Exp. Med. 183, 1879–1892 (1996).

    Article  CAS  Google Scholar 

  10. Wang, Z. et al. Nature 423, 555–560 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anjana Rao.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bandukwala, H., Rao, A. 'Nurr'ishing Treg cells: Nr4a transcription factors control Foxp3 expression. Nat Immunol 14, 201–203 (2013). https://doi.org/10.1038/ni.2546

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2546

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing