Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Paneth cells: targets of friendly fire

Nature Immunology volume 14, pages 114–116 (2013)Cite this article

Subjects

Severe intestinal pathology associated with infection with Toxoplasma gondii is a result of the loss of Paneth cells, an unexpected side effect of the secretion of IFN-γ by protective CD4+ T cells in the intestinal mucosa.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Parasite control during immune responses to infection with T. gondii causes collateral damage in the gut.

Marina Corral

References

  1. Jankovic, D., Kugler, D.G. & Sher, A. Mucosal Immunol. 3, 239–246 (2010).

    Article  CAS  Google Scholar 

  2. Pifer, R. & Yarovinsky, F. Trends Parasitol. 27, 388–393 (2011).

    Article  CAS  Google Scholar 

  3. Raetz, M. et al. Nat. Immunol. 14, 136–142 (2013).

    Article  CAS  Google Scholar 

  4. Bevins, C.L. & Salzman, N.H. Nat. Rev. Microbiol. 9, 356–368 (2011).

    Article  CAS  Google Scholar 

  5. Clevers, H.C. & Bevins, C.L. Annu. Rev. Physiol. 10.1146/annurev-physiol-030212–183744 (2013).

  6. Montoya, J.G. & Liesenfeld, O. Lancet 363, 1965–1976 (2004).

    Article  CAS  Google Scholar 

  7. Srinivasan, A. et al. J. Immunol. 178, 6342–6349 (2007).

    Article  CAS  Google Scholar 

  8. Freeman, B.E., Hammarlund, E., Raue, H.P. & Slifka, M.K. Proc. Natl. Acad. Sci. USA 109, 9971–9976 (2012).

    Article  CAS  Google Scholar 

  9. Egan, C.E., Cohen, S.B. & Denkers, E.Y. Immunol. Cell Biol. 90, 668–675 (2012).

    Article  CAS  Google Scholar 

  10. Xavier, R.J. & Podolsky, D.K. Nature 448, 427–434 (2007).

    Article  CAS  Google Scholar 

  11. Wehkamp, J. & Stange, E.F. J. Crohns Colitis 4, 523–531 (2010).

    Article  Google Scholar 

  12. Bevins, C.L. & Salzman, N.H. Cell. Mol. Life Sci. 68, 3675–3685 (2011).

    Article  CAS  Google Scholar 

  13. Cadwell, K. et al. Nature 456, 259–263 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Stephen J. McSorley is with the Center for Comparative Medicine, UC Davis School of Medicine, University of California, Davis, Davis, California, USA.,

    Stephen J McSorley

  2. Charles L. Bevins is in the Department of Microbiology and Immunology, UC Davis School of Medicine, University of California, Davis, Davis, California, USA.,

    Charles L Bevins

Authors
  1. Stephen J McSorley
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charles L Bevins
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Stephen J McSorley or Charles L Bevins.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

McSorley, S., Bevins, C. Paneth cells: targets of friendly fire. Nat Immunol 14, 114–116 (2013). https://doi.org/10.1038/ni.2519

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2519

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing