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T. rex attacks the lysosome

Nature Immunology volume 14, pages 10–12 (2013)Cite this article

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The mechanisms by which cells detect and fight foreign organisms is crucial for the host defense against infection. The sensing of cytosolic DNA is pivotal in this process, is kept in check by the exonuclease Trex1 and has been linked to lysosomal biogenesis via the transcription factor TFEB in an interferon-independent manner.

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Figure 1: Sensing of cytosolic DNA, kept in check by Trex1, has been linked to lysosomal biogenesis in the absence of interferons.

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Authors and Affiliations

  1. Nuffield Department of Medicine, Anna Katharina Simon is with the Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, and Biomedical Research Centre Translational Immunology Lab, John Radcliffe Hospital, Oxford, UK.,

    Anna Katharina Simon

  2. Italy; the Department of Pediatrics, Italy; the Department of Molecular and Human Genetics, Andrea Ballabio is with the Telethon Institute of Genetics and Medicine, Naples, Medical Genetics, Federico II University, Naples, Baylor College of Medicine, Houston, Texas, USA; and the Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas, USA.,

    Andrea Ballabio

  3. the Department of Pediatrics, Medical Genetics, Federico II University, Naples, Italy, the Department of Pediatrics, Medical Genetics, Federico II University, Naples, Italy,

    Andrea Ballabio

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  1. Anna Katharina Simon
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Correspondence to Andrea Ballabio.

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Simon, A., Ballabio, A. T. rex attacks the lysosome. Nat Immunol 14, 10–12 (2013). https://doi.org/10.1038/ni.2497

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