Protection against recurrent infections requires the generation of memory B cells and persistent antibody production. An adaptor complex of DOCK8-MyD88-Pyk2 now links signaling via TLR9 to activation of the transcription factor STAT3 and the establishment of serological memory.
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Werner, M., Jumaa, H. DOCKing innate to adaptive signaling for persistent antibody production. Nat Immunol 13, 525–526 (2012). https://doi.org/10.1038/ni.2317
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DOI: https://doi.org/10.1038/ni.2317
