After class switching in naive B cells, memory B cells and plasma cells that produce immunoglobulin E (IgE+ cells) develop through a germinal-center IgE+ intermediate cell without an IgG1 phase. In addition, cellular IgE memory resides in IgE+ memory B cells, and IgG1+ memory B cells are not an important source of IgE memory.
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Akdis, M., Akdis, C. IgE class switching and cellular memory. Nat Immunol 13, 312–314 (2012). https://doi.org/10.1038/ni.2266
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DOI: https://doi.org/10.1038/ni.2266
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