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IL-2 and IL-15 signaling complexes: different but the same

Nature Immunology volume 13, pages 1141–1142 (2012)Cite this article

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Interleukin 2 (IL-2) and IL-15 use receptors with the same signaling subunits. New structural data show that the signaling complexes they form are topologically nearly identical, which suggests that other factors are responsible for the distinct signaling properties of these complexes.

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Figure 1: Signaling by IL-2 and IL-15.

Debbie Maizels

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Authors and Affiliations

  1. Shinji Ikemizu and Mami Chirifu are in the Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.,

    Shinji Ikemizu & Mami Chirifu

  2. Radcliffe Department of Medicine, Simon J. Davis and, at present, Mami Chirifu are at the Weatherall Institute of Molecular Medicine and Medical Research Council Human Immunology Unit, Oxford, UK.,

    Mami Chirifu & Simon J Davis

Authors
  1. Shinji Ikemizu
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  2. Mami Chirifu
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  3. Simon J Davis
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Correspondence to Shinji Ikemizu or Simon J Davis.

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The authors declare no competing financial interests.

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Ikemizu, S., Chirifu, M. & Davis, S. IL-2 and IL-15 signaling complexes: different but the same. Nat Immunol 13, 1141–1142 (2012). https://doi.org/10.1038/ni.2472

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