In addition to its recognized function as an enzyme that catalyzes tryptophan, indoleamine 2,3-dioxygenase (IDO) acts as an intracellular signal transducer, in response to transforming growth factor-β (TGF-β), to induce a stably regulatory phenotype in plasmacytoid dendritic cells.
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Chen, W. IDO: more than an enzyme. Nat Immunol 12, 809–811 (2011). https://doi.org/10.1038/ni.2088
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DOI: https://doi.org/10.1038/ni.2088
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