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IKKα takes control of canonical NF-κB activation

Nature Immunology volume 12, pages 815–816 (2011)Cite this article

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The kinase IKKα has a well-described activating role in the noncanonical transcription factor NF-κB pathway. Evidence now suggests that IKKα also inhibits the canonical NF-κB pathway by phosphorylating the scaffold protein TAX1BP1 to promote the assembly of the A20 ubiquitin-editing complex.

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Figure 1: IKKα inhibits the canonical NF-κB pathway via phosphorylation of TAX1BP1.

Katie Vicari

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Authors and Affiliations

  1. Christiane Pelzer and Margot Thome are in the Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.,

    Christiane Pelzer & Margot Thome

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  1. Christiane Pelzer
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  2. Margot Thome
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Correspondence to Margot Thome.

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Pelzer, C., Thome, M. IKKα takes control of canonical NF-κB activation. Nat Immunol 12, 815–816 (2011). https://doi.org/10.1038/ni.2082

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