Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Defeating sepsis by misleading MyD88

An Addendum to this article was published on 19 July 2011

This article has been updated

Helminth parasites are adept at dampening immunity. New data showing that intracellular degradative pathways are manipulated have important implications for therapy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Helminth products interfere with DC signaling and processing.

Change history

  • 24 June 2011

    The article to which this News and Views refers has been retracted (http://www.nature.com/ni/journal/v12/n4/abs/ni.2004.html). Nature Immunology wishes to inform readers that some of the comments made in this News and Views, although made in good faith based on the article's conclusions, may no longer be valid.

References

  1. Creagh, E.M. & O'Neill, L.A.J. Trends Immunol. 27, 352–357 (2006).

    Article  CAS  Google Scholar 

  2. Figdor, C.G., van Kooyk, Y. & Adema, G.J. Nat. Rev. Immunol. 2, 77–84 (2002).

    Article  CAS  Google Scholar 

  3. Puneet, P. et al. Nat. Immunol. 12, 344–351 (2011).

    Article  CAS  Google Scholar 

  4. Hewitson, J.P., Grainger, J.R. & Maizels, R.M. Mol. Biochem. Parasitol. 167, 1–11 (2009).

    Article  CAS  Google Scholar 

  5. Levine, B., Mizushima, N. & Virgin, H.W. Nature 469, 323–335 (2011).

    Article  CAS  Google Scholar 

  6. Manoury, B., Gregory, W.F., Maizels, R.M. & Watts, C. Curr. Biol. 11, 447–451 (2001).

    Article  CAS  Google Scholar 

  7. Grainger, J.R. et al. J. Exp. Med. 207, 2331–2341 (2010).

    Article  CAS  Google Scholar 

  8. Correale, J. & Farez, M. J. Immunol. 183, 5999–6012 (2009).

    Article  CAS  Google Scholar 

  9. Everts, B., Smits, H.H., Hokke, C.H. & Yazdankbakhsh, M. Eur. J. Immunol. 40, 1525–1537 (2010).

    Article  CAS  Google Scholar 

  10. Donnelly, S. et al. J. Biol. Chem. 285, 3383–3392 (2010).

    Article  CAS  Google Scholar 

  11. Steinfelder, S. et al. J. Exp. Med. 206, 1681–1690 (2009).

    Article  CAS  Google Scholar 

  12. Ritter, M. et al. Proc. Natl. Acad. Sci. USA 107, 20459–20464 2010).

    Article  CAS  Google Scholar 

  13. Harnett, W. & Harnett, M.M. Adv. Exp. Med. Biol. 666, 88–94 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rick M Maizels.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Smith, K., Maizels, R. Defeating sepsis by misleading MyD88. Nat Immunol 12, 284–286 (2011). https://doi.org/10.1038/ni0411-284

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0411-284

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing