MicroRNAs regulate many biological functions. Research now indicates that intestinal epithelial microRNAs might also regulate the differentiation of goblet cells and promote T helper type 2 immune responses to parasite infection.
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References
Biton, M. et al. Nat. Immunol. 12, 239–246 (2011).
van der Flier, L.G. & Clevers, H. Annu. Rev. Physiol. 71, 241–260 (2009).
Rimoldi, M. et al. Nat. Immunol. 6, 507–514 (2005).
Dahan, S., Roth-Walter, F., Arnaboldi, P., Agarwal, S. & Mayer, L. Immunol. Rev. 215, 243–253 (2007).
Atarashi, K. et al. Science 331, 337–341 (2011).
Gaboriau-Routhiau, V. et al. Immunity 31, 677–689 (2009).
Ivanov, I.I. et al. Cell 139, 485–498 (2009).
Maizels, R.M., Pearce, E.J., Artis, D., Yazdanbakhsh, M. & Wynn, T.A. J. Exp. Med. 206, 2059–2066 (2009).
Bartel, D.P. Cell 116, 281–297 (2004).
McKenna, L.B. et al. Gastroenterology 139, 1654–1664, (2010).
Wu, F. et al. Inflamm. Bowel Dis. 16, 1729–1738 (2010).
Ishikawa, N. et al. Gastroenterology 113, 542–549 (1997).
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Goto, Y., Kiyono, H. Epithelial cell microRNAs in gut immunity. Nat Immunol 12, 195–197 (2011). https://doi.org/10.1038/ni0311-195
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DOI: https://doi.org/10.1038/ni0311-195
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