Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Explaining discordant coordination

Nature Immunology volume 12, pages 16–17 (2011)Cite this article

Subjects

TH2 cells control immune responses to helminth infection and contribute to the development of allergic asthma. A single intronic enhancer element in Il4 can regulate TH2 differentiation and susceptibility to allergic asthma via interaction with the transcription factor GATA-3.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Three models of regulation of Il4, Il13 and Il5 by TH2 locus cis elements in TH2 cell.

References

  1. Tanaka, S. et al. Nat. Immunol. 12, 77–85 (2011).

    Article  CAS  Google Scholar 

  2. Ansel, K.M., Djuretic, I., Tanasa, B. & Rao, A. Annu. Rev. Immunol. 24, 607–656 (2006).

    Article  CAS  Google Scholar 

  3. Avni, O. et al. Nat. Immunol. 3, 643–651 (2002).

    Article  CAS  Google Scholar 

  4. Baguet, A. & Bix, M. Proc. Natl. Acad. Sci. USA 101, 11410–11415 (2004).

    Article  CAS  Google Scholar 

  5. Fields, P.E., Kim, S.T. & Flavell, R.A. J. Immunol. 169, 647–650 (2002).

    Article  CAS  Google Scholar 

  6. Spilianakis, C.G. & Flavell, R.A. Nat. Immunol. 5, 1017–1027 (2004).

    Article  CAS  Google Scholar 

  7. Lee, H.J. et al. J. Exp. Med. 192, 105–115 (2000).

    Article  CAS  Google Scholar 

  8. Kelso, A., Groves, P., Ramm, L. & Doyle, A.G. Int. Immunol. 11, 617–621 (1999).

    Article  CAS  Google Scholar 

  9. Hural, J.A., Kwan, M., Henkel, G., Hock, M.B. & Brown, M.A. J. Immunol. 165, 3239–3249 (2000).

    Article  CAS  Google Scholar 

  10. Loots, G.G. et al. Science 288, 136–140 (2000).

    Article  CAS  Google Scholar 

  11. Solymar, D.C., Agarwal, S., Bassing, C.H., Alt, F.W. & Rao, A. Immunity 17, 41–50 (2002).

    Article  CAS  Google Scholar 

  12. Tanaka, S. et al. Immunity 24, 689–701 (2006).

    Article  CAS  Google Scholar 

  13. Lee, G.R., Fields, P.E. & Flavell, R.A. Immunity 14, 447–459 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Melanie Van Stry and Mark Bix are in the Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.,

    Melanie Van Stry & Mark Bix

Authors
  1. Melanie Van Stry
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mark Bix
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark Bix.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Van Stry, M., Bix, M. Explaining discordant coordination. Nat Immunol 12, 16–17 (2011). https://doi.org/10.1038/ni0111-16

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0111-16

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing