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The biological century: coming to terms with risk in the life sciences

Although the life sciences promise huge benefits, the possibility of doing harm from deliberate misuse of knowledge is an increasingly worrisome issue. Discussion and mitigation of these risks by life scientists must be encouraged.

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Figure 1: Risk of harm from misuse of the life sciences: components and trends.

References

  1. Benford, G. & Zebrowski, G. Magazine of Fantasy & Science Fiction 73–82 (August 1992).

    Google Scholar 

  2. Federal Register. Notice: Screening Framework Guidance for Synthetic Double-Stranded DNA Providers. <http://www.thefederalregister.com/d.p/2009-11-27-E9-28328> (27 November 2009).

  3. Casadevall, A. & Relman, D.A. Nat. Rev. Microbiol. 8, 149–154 (2010).

    Article  CAS  Google Scholar 

  4. Petro, J.B. & Relman, D.A. Science 302, 1898 (2003).

    Article  CAS  Google Scholar 

  5. Mowatt-Larssen, R. Al Qaeda Weapons of Mass Destruction Threat: Hype or Reality? 1–32 (Belfer Center for Science and International Affairs, Harvard University, Cambridge, MA, 25 January 2010).

    Google Scholar 

  6. National Research Council. Biotechnology Research in an Age of Terrorism: Confronting the 'Dual Use' Dilemma (National Academies Press, Washington, DC, 2003).

  7. Institute of Medicine. Globalization, Biosecurity, and the Future of the Life Sciences (National Academies Press, Washington, DC, 2006).

  8. Stanford, M.M. & McFadden, G. Trends Immunol. 26, 339–345 (2005).

    Article  CAS  Google Scholar 

  9. ten Bokum, A.M.C., Movahedzadeh, F., Frita, R., Bancroft, G.J. & Stoker, N.G. Trends Microbiol. 16, 436–441 (2008).

    Article  CAS  Google Scholar 

  10. Institute of Medicine. Microbial Threats to Health: Emergence, Detection, and Response (National Academies Press, Washington, DC, 2005).

  11. U.S. Department of Homeland Security. Homeland Security Presidential Directive 10: Biodefense for the 21st Century. <http://www.dhs.gov/xabout/laws/gc_1217605824325.shtm> (2004).

  12. U.S. Department of Homeland Security. Homeland Security Presidential Directive 18: Medical Countermeasures against Weapons of Mass Destruction. <http://www.dhs.gov/xabout/laws/gc_1219175362551.shtm> (2007).

  13. National Security Council. National Strategy for Countering Biological Threats. <http://www.whitehouse.gov/sites/default/files/National_Strategy_for_Countering_BioThreats.pdf> (2009).

  14. Berg, P. Meetings that changed the world: Asilomar 1975: DNA modification secured. Nature 455, 290–291 (2008).

    Article  CAS  Google Scholar 

  15. Graham, B. et al. World at Risk: The Report of the Commission on the Prevention of WMD Proliferation and Terrorism. (Random House, New York, 2008).

    Google Scholar 

Download references

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Correspondence to David A Relman.

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Relman, D. The biological century: coming to terms with risk in the life sciences. Nat Immunol 11, 275–278 (2010). https://doi.org/10.1038/ni0410-275

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