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Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

Nature Immunology volume 11, pages 114–120 (2010)Cite this article

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Abstract

Bcl-6 and Blimp-1 have recently been identified as key transcriptional regulators of effector and memory differentiation in CD4+ T cells and CD8+ T cells. Bcl-6 and Blimp-1 were previously known to be critical regulators of effector and memory differentiation of B lymphocytes. The new findings unexpectedly point to the Bcl-6 and Blimp-1 regulatory axis as a ubiquitous mechanism for controlling effector and memory lymphocyte differentiation and function. Bcl-6 and Blimp-1 are antagonistic transcription factors and can function as a self-reinforcing genetic switch for cell-fate decisions. However, their influences in different lymphocytes are complex. Here we review and examine the commonalities and differences in the functions of these transcription factors in CD4+ follicular helper TFH lymphocytes, effector CD8+ T lymphocytes and B lymphocytes.

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Figure 1: Bcl-6 and Blimp-1 are reciprocally antagonistic transcription factors.
Figure 2: Roles of Bcl-6 and Blimp-1 in B cell differentiation.
Figure 3: Roles of Bcl-6 and Blimp-1 in T cell differentiation.
Figure 4: Functional effects of different amounts of Bcl-6 and Blimp-1 expression.

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Acknowledgements

Supported by a Pew Scholar Award and the National Institutes of Health (072543 and 063107 to S.C.).

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  1. Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA

    Shane Crotty & Robert J Johnston

  2. Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, USA

    Shane Crotty & Robert J Johnston

  3. Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA

    Stephen P Schoenberger

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Correspondence to Shane Crotty.

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Crotty, S., Johnston, R. & Schoenberger, S. Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat Immunol 11, 114–120 (2010). https://doi.org/10.1038/ni.1837

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