1. Thomas Boehm is with the Max-Planck Institute of Immunobiology, Freiburg, Germany.
   e-mail: boehm@immunbio.mpg.de

Abstract

Jawless fishes, the 'sister' group of jawed vertebrates, use leucine-rich repeat–containing proteins as antigen receptors. New work shows that the two isotypes of variable lymphocyte receptors are expressed in distinct lymphocyte lineages, which indicates that lymphocytes resembling T cells and B cells are an ancient feature of all vertebrates.

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