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Nature Immunology 10, 683 - 685 (2009)
doi:10.1038/ni0709-683
ASMase: the tailor of cytotoxic T cell granule exocytosis
Christian Bogdan1
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Christian Bogdan is in the Microbiology Institute, Clinical Microbiology, Immunology and Hygiene, University Clinic of Erlangen, Erlangen, Germany.
e-mail:e-mail: christian.bogdan@uk-erlangen.de
Abstract
Deficiency in acid sphingomyelinase causes lysosomal storage of sphingomyelin, mediates resistance to stress-induced apoptosis and alters susceptibility to certain infections. New work links acid sphingomyelinase to the granule exocytosis of cytotoxic T cells.
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RESEARCH
Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytesNature Immunology Article (01 Jul 2009)
