1. Thomas A. Wynn is in the Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
   e-mail: e-mail: twynn@niaid.nih.gov

Abstract

Dendritic cells are best known as antigen-presenting cells that initiate adaptive immune responses. Three new papers suggest that basophils initiate allergen- and helminth-driven CD4⁺ T helper type 2 responses by functioning as antigen-presenting cells in draining lymph nodes.

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