1. Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
   e-mail: vkuchroo@rics.bwh.harvard.edu

Abstract

T helper type 1 cells (T_H1 cells) serve a dominant function in T cell–mediated colitis. New work reports that interleukin 17A, an effector cytokine required for the development of autoimmune tissue inflammation, directly inhibits T_H1 development by suppressing the expression of key T_H1-associated genes and therefore regulates T_H1 cell–mediated colitis.

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