News and Views
Nature Immunology 10, 565 - 566 (2009)
doi:10.1038/ni0609-565
Treg cells meet their limit
Kristin A Hogquist1 & Amy E Moran1
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Department of Laboratory Medicine and Pathology at the University of Minnesota, Minneapolis, Minnesota, USA.
e-mail: hogqu001@umn.edu
Abstract
T cell antigen receptor (TCR)-transgenic models have been enormously influential in studies of T cell development in the thymus, particularly in terms of positive and negative selection. New transgenic mice produced with TCR genes cloned from regulatory T cells show that TCR specificity does 'instruct' regulatory T cell fate, within limits.
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