News and Views
Nature Immunology 10, 563 - 564 (2009)
doi:10.1038/ni0609-563
Hybrid Treg cells: steel frames and plastic exteriors
Michael J Barnes1 & Fiona Powrie1
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Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
e-mail: fiona.powrie@path.ox.ac.uk
Abstract
Regulatory T cells have the remarkable ability to suppress immune responses driven by different types of effector T cells. Two recent studies, documenting important functions for T-bet and IRF4 in regulatory T cells, demonstrate that this ability requires the expression of transcription factors typically associated with effector T cell function.
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