News and Views
Nature Immunology 10, 457 - 458 (2009)
doi:10.1038/ni0509-457
The Foxo and the hound: chasing the in vivo regulation of T cell populations during infection
Elia D Tait1 & Christopher A Hunter1
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Elia D. Tait and Christopher A. Hunter are in the Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
e-mail: chunter@vet.upenn.edu
Abstract
T cell expansion and contraction during the immune response to pathogens are regulated by a wide variety of cell-intrinsic and cell-extrinsic factors. A new study identifies a role for CTLA-4 signaling and activation of the Foxo3 transcription factor in modulating T cell populations.
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