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Nature Immunology 10, 451 - 453 (2009)
doi:10.1038/ni0509-451
Local advantage: skin DCs prime; skin memory T cells protect
Akiko Iwasaki1
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Akiko Iwasaki is in the Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
e-mail: akiko.iwasaki@yale.edu
Abstract
How the immune system responds to local infection and establishes protective immunity in susceptible tissues remains unclear. Two new studies show that local tissue-resident dendritic cells prime cytotoxic T lymphocyte responses and that memory cytotoxic T lymphocytes remain in the tissue to provide antiviral immunity.
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