Article abstract
Nature Immunology 10, 488 - 495 (2009)
Published online: 6 April 2009 | doi:10.1038/ni.1724
Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
Sammy Bedoui1,2,3, Paul G Whitney1,3, Jason Waithman1,2,3, Liv Eidsmo1, Linda Wakim1, Irina Caminschi2, Rhys S Allan1, Magdalena Wojtasiak1, Ken Shortman2, Francis R Carbone1, Andrew G Brooks1 & William R Heath1,2
Abstract
Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103+ dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens. Only the CD103+ subset efficiently presented antigens of herpes simplex virus type 1 to naive CD8+ T cells, although all subsets presented these antigens to CD4+ T cells. This showed that CD103+ DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation. This was supported by data showing only CD103+ DCs efficiently cross-presented skin-derived self antigens. This indicates CD103+ DCs are the main migratory subtype able to cross-present viral and self antigens, which identifies another level of specialization for skin DCs.
- The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia.
- The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
- These authors contributed equally to this work.
Correspondence to: William R Heath1,2 e-mail: wrheath@unimelb.edu.au
Correspondence to: Francis R Carbone1 e-mail: fcarbone@unimelb.edu.au
Correspondence to: Andrew G Brooks1 e-mail: agbrooks@unimelb.edu.au
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