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Nature Immunology 10, 367–369 (1 April 2009) | doi:10.1038/ni0409-367
AID and RPA: PKA makes the connection local
Abstract
Activation-induced cytidine deaminase (AID) is the key enzyme responsible for the induction of somatic hypermutation and class switching in immunoglobulin genes. How AID is targeted to the immunoglobulin heavy- and light-chain loci and, in particular, how the enzyme is able to access its single-stranded DNA substrate are important issues yet to be resolved.
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