Borrowing words, or claiming them? - p225

doi:10.1038/ni0309-225

Journals are taking steps to stem of the practice of plagiarism.

Full Text - Borrowing words, or claiming them? | PDF (192 KB) - Borrowing words, or claiming them?

Revolving doors: from academia to industry and back again - pp227 - 229

Ross M Kedl

doi:10.1038/ni0309-227

Is it possible to return from the industrial sector back to academia? Although academic scientists have traditionally perceived this to be akin to winning the Nobel prize, the personal experience of Ross Kedl suggests that the reality is something quite different altogether.

Full Text - Revolving doors: from academia to industry and back again | PDF (308 KB) - Revolving doors: from academia to industry and back again

Developing NKT cells need their calcium - pp231 - 233

Dale I Godfrey, Sanda Stankovic & Alan G Baxter

doi:10.1038/ni0309-231

Although the development of natural killer T cells is a T cell antigen receptor–dependent process, the signaling pathways involved are poorly defined. New data demonstrate that the calcineurin–transcription factor NFAT pathway exerts a critical influence on this process by controlling the transcription factor Egr2.

Full Text - Developing NKT cells need their calcium | PDF (419 KB) - Developing NKT cells need their calcium

See also: Article by Lazarevic et al.

Intrinsic mRNA stability helps compose the inflammatory symphony - pp233 - 234

Paul Anderson

doi:10.1038/ni0309-233

The intrinsic stability of mRNA is important in the regulation of gene expression. New data show that the intrinsic stability of tumor necrosis factor–induced mRNA transcripts strongly influences the coordinated expression of genes that promote distinct phases of the inflammatory response.

Full Text - Intrinsic mRNA stability helps compose the inflammatory symphony | PDF (276 KB) - Intrinsic mRNA stability helps compose the inflammatory symphony

See also: Article by Hao & Baltimore

Deciding the decider: Mef2c in hematopoiesis - pp235 - 236

Rachel M Gerstein

doi:10.1038/ni0309-235

Factors influencing progenitor cell 'choice' between lymphoid and myeloid lineage fates are incompletely understood. New work implicates the transcription factor Mef2c as one component needed to promote lymphoid and suppress myeloid lineage differentiation.

Full Text - Deciding the decider: Mef2c in hematopoiesis | PDF (224 KB) - Deciding the decider: Mef2c in hematopoiesis

See also: Article by Stehling-Sun et al.

Don't leave home without it: the IL-23 visa to T_H-17 cells - pp236 - 238

Yeonseok Chung & Chen Dong

doi:10.1038/ni0309-236

Interleukin 23 is tightly associated with T_H-17 cell–mediated inflammation and autoimmunity. A new study of mice deficient in its receptor shows that interleukin 23 is required for the terminal differentiation of T_H-17 cells in vivo.

Full Text - Don't leave home without it: the IL-23 visa to TH-17 cells | PDF (378 KB) - Don't leave home without it: the IL-23 visa to TH-17 cells

See also: Article by McGeachy et al.

Research Highlights - p239

doi:10.1038/ni0309-239

Full Text - Research Highlights | PDF (115 KB) - Research Highlights

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis - pp241 - 247

Luigi Franchi, Tatjana Eigenbrod, Raúl Muñoz-Planillo & Gabriel Nuñez

doi:10.1038/ni.1703

Abstract - | Full Text - The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis | PDF (449 KB) - The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF- signaling pathway in Caenorhabditis elegans epidermis - pp249 - 256

Olivier Zugasti & Jonathan J Ewbank

doi:10.1038/ni.1700

In worms, antimicrobial peptides contribute to the defense against pathogen infection. Ewbank and colleagues describe a noncanonical signaling pathway required for the induction of one particular family of antimicrobial peptides.

Abstract - | Full Text - Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF- signaling pathway in Caenorhabditis elegans epidermis | PDF (557 KB) - Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF- signaling pathway in Caenorhabditis elegans epidermis | Supplementary information

The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation - pp257 - 265

Zhong-Jian Shen, Stephane Esnault, Anna Schinzel, Christoph Borner & James S Malter

doi:10.1038/ni.1697

The mechanism by which cytokines suppress Bax activation and eosinophil apoptosis are not well understood. Malter and colleagues pinpoint a function for the peptidyl-prolyl isomerase Pin1 in mediating cytokine-induced suppression of Bax activation.

Abstract - | Full Text - The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation | PDF (687 KB) - The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation | Supplementary information

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome - pp266 - 272

Tilmann Bürckstümmer, Christoph Baumann, Stephan Blüml, Evelyn Dixit, Gerhard Dürnberger, Hannah Jahn, Melanie Planyavsky, Martin Bilban, Jacques Colinge, Keiryn L Bennett & Giulio Superti-Furga

doi:10.1038/ni.1702

The identity of the cytoplasmic DNA receptor that activates the inflammasome has remained elusive. Superti-Furga and colleagues use a proteomics screen to identity AIM2 as the DNA sensor for the inflammasome.

Abstract - | Full Text - An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome | PDF (967 KB) - An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome | Supplementary information

Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function - pp273 - 280

Abdur Rub, Ranadhir Dey, Meenakshi Jadhav, Rohan Kamat, Santhosh Chakkaramakkil, Subrata Majumdar, Robin Mukhopadhyaya & Bhaskar Saha

doi:10.1038/ni.1705

CD40 signals induce the production of interleukin 12 and interleukin 10 in uninfected and Leishmania major–infected macrophages, respectively. Saha and colleagues suggest that L. major–induced cholesterol depletion facilitates the assembly of distinct CD40 signalosomes.

Abstract - | Full Text - Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function | PDF (728 KB) - Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function | Supplementary information

The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules - pp281 - 288

Shengli Hao & David Baltimore

doi:10.1038/ni.1699

Genes induced by inflammatory stimuli are expressed in a precise temporal order. Baltimore and colleagues show that mRNA stability exerts strong influence over the kinetics of the induction of genes encoding inflammatory molecules.

Abstract - | Full Text - The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules | PDF (521 KB) - The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules | Supplementary information

See also: News and Views by Anderson

Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c - pp289 - 296

Sandra Stehling-Sun, Jessica Dade, Stephen L Nutt, Rodney P DeKoter & Fernando D Camargo

doi:10.1038/ni.1694

Myeloid and lymphoid cells are derived from the same multipotent progenitor cell. Camargo and colleagues show that the transcription factor Mef2c restricts myeloid differentiation to favor production of B, T and natural killer cells.

Abstract - | Full Text - Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c | PDF (927 KB) - Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c | Supplementary information

See also: News and Views by Gerstein

Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function - pp297 - 305

Mario-Ernesto Cruz-Munoz, Zhongjun Dong, Xiaochu Shi, Shaohua Zhang & André Veillette

doi:10.1038/ni.1693

The biological function of the SLAM family receptor CRACC is not known. Using a CRACC-deficient mouse, Veillette and colleagues show that CRACC can activate or inhibit natural killer cells, depending on the availability of the adaptor EAT-2.

Abstract - | Full Text - Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function | PDF (749 KB) - Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function | Supplementary information

The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells - pp306 - 313

Vanja Lazarevic, Alfred J Zullo, Michelle N Schweitzer, Tracy L Staton, Elena M Gallo, Gerald R Crabtree & Laurie H Glimcher

doi:10.1038/ni.1696

The signals that regulate the development of natural killer T cells are not completely understood. Glimcher and colleagues document an essential function for the transcription factor Egr2 in the maturation of these cells.

Abstract - | Full Text - The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells | PDF (755 KB) - The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells | Supplementary information

See also: News and Views by Godfrey et al.

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo - pp314 - 324

Mandy J McGeachy, Yi Chen, Cristina M Tato, Arian Laurence, Barbara Joyce-Shaikh, Wendy M Blumenschein, Terrill K McClanahan, John J O'Shea & Daniel J Cua

doi:10.1038/ni.1698

Whether interleukin 23 (IL-23) affects the differentiation of or simply the maintenance of IL-17–producing helper T cells (T_H-17 cells) is unclear. Cua and colleagues show that IL-23 is required for the full differentiation and proliferation of effector T_H-17 cells in vivo.

Abstract - | Full Text - The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo | PDF (884 KB) - The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo | Supplementary information

See also: News and Views by Chung & Dong