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Nature Immunology 10, 233 - 234 (2009)
doi:10.1038/ni0309-233
Intrinsic mRNA stability helps compose the inflammatory symphony
Paul Anderson1
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Paul Anderson is in the Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
e-mail: panderson@rics.bwh.harvard.edu
Abstract
The intrinsic stability of mRNA is important in the regulation of gene expression. New data show that the intrinsic stability of tumor necrosis factor–induced mRNA transcripts strongly influences the coordinated expression of genes that promote distinct phases of the inflammatory response.
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