News and Views
Nature Immunology 10, 134 - 136 (2009)
doi:10.1038/ni0209-134
An unexpected twist for autophagy in Crohn's disease
Tamaki Yano1 & Shoichiro Kurata1
- Tamaki Yano and Shoichiro Kurata are in the Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan. e-mail: kurata@mail.pharm.tohoku.ac.jp
Abstract
Autophagy has been linked to inflammatory bowel disease. Studies of two different mouse strains deficient in the autophagy-related gene product Atg16L1 now show that autophagy is important in regulating the secretory function of Paneth cells and the production of inflammatory cytokines in the intestine.
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