News and Views
Nature Immunology 10, 1141 - 1143 (2009)
doi:10.1038/ni1109-1141
The gut feeling of Treg cells: IL-10 is the silver lining during colitis
Derya Unutmaz1 & Bali Pulendran2
- Derya Unutmaz is in the Department of Microbiology, Department of Pathology, New York University School of Medicine, New York, New York, USA.
- Bali Pulendran is with the Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Correspondence to: Derya Unutmaz1 e-mail: derya@mac.com
Correspondence to: Bali Pulendran2 e-mail: bpulend@emory.edu
Abstract
Regulatory T cells that express the transcription factor Foxp3 are pivotal in suppressing autoimmune responses. A report in this issue describes a key role for interleukin 10 produced by lamina propria macrophages in maintaining Foxp3 expression during inflammatory responses in the intestine.
