1. Peter J. Murray is in the Department of Infectious Diseases and the Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
   e-mail: peter.murray@stjude.org

Abstract

Nod2 is a cytoplasmic Nod-like receptor protein that detects the peptidoglycan subfragment muramyl dipeptide. New work shows that Nod2 also has an important role in recognizing viruses and in triggering interferon production during viral infection.

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