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Nature Immunology 10, 1051 - 1052 (2009)
doi:10.1038/ni1009-1051
A defining factor for natural killer cell development
James P Di Santo1
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James P. Di Santo is in the Cytokines and Lymphoid Development Unit, Institut Pasteur, and Institut National de la Santé et de la Recherche Médicale U668, Paris, France.
e-mail: disanto@pasteur.fr
Abstract
Transcription factors are critical regulators of cell fate in the hemato-lymphoid system. New evidence indicates that the basic leucine zipper transcription factor E4BP4 (also known as NFIL3) is essential for natural killer cell specification.
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