Article abstract
Nature Immunology 10, 1073 - 1080 (2009)
Published online: 23 August 2009 | doi:10.1038/ni.1782
Activation of innate immune antiviral responses by Nod2
Ahmed Sabbah1, Te Hung Chang1, Rosalinda Harnack1, Victoria Frohlich2, Kaoru Tominaga2,3, Peter H Dube1, Yan Xiang1 & Santanu Bose1
Abstract
Pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-like helicase (RLH) receptors, are involved in innate immune antiviral responses. Here we show that nucleotide-binding oligomerization domain 2 (Nod2) can also function as a cytoplasmic viral PRR by triggering activation of interferon-regulatory factor 3 (IRF3) and production of interferon-
(IFN-). After recognition of a viral ssRNA genome, Nod2 used the adaptor protein MAVS to activate IRF3. Nod2-deficient mice failed to produce interferon efficiently and showed enhanced susceptibility to virus-induced pathogenesis. Thus, the function of Nod2 as a viral PRR highlights the important function of Nod2 in host antiviral defense mechanisms.
- Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
- Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
- Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Correspondence to: Santanu Bose1 e-mail: bose@uthscsa.edu
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