News and Views
Nature Immunology 10, 16 - 18 (2009)
doi:10.1038/ni0109-16
A new function for the RNA-editing enzyme ADAR1
Hisashi Iizasa1 & Kazuko Nishikura1
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Hisashi Iizasa and Kazuko Nishikura are in the Department of Gene Expression and Regulation, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
e-mail: kazuko@wistar.org
Abstract
ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.
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