Nature Immunology
1, 521 - 525 (2000)
doi:10.1038/82782
Immune suppression and skin cancer development: regulation by NKT cells
Angus M. Moodycliffe1, 3, Dat Nghiem1, 2, Gavin Clydesdale1
& Stephen E. Ullrich1, 21
The Department of Immunology, The University of Texas,
M. D. Anderson Cancer Center, 1515 Holcombe Blvd.,
Houston, TX 77030-4009, USA. 2
The Graduate School of Biomedical Sciences,
1515 Holcombe Blvd., Houston, TX 77030-4009
, USA. 3
Present address: The Department of Nutrition, Nestlé
Research Center, PO Box 44, 1000 Lausanne, Vers-Chez-Blanc
, Switzerland.
Correspondence should be addressed to Stephen E. Ullrich sullrich@notes.mdacc.tmc.eduUltraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced
immune suppression is mediated by antigen-specific T cells, which can transfer
suppression to normal recipients. These cells are essential for controlling
skin cancer development in the UV-irradiated host and in suppressing other
immune responses, such as delayed-type hypersensitivity. Despite their importance
in skin cancer development, their exact identity has remained elusive. We
show here that natural killer T cells from UV-irradiated donor mice function
as suppressor T cells and play a critical role in regulating the growth of
UV-induced skin cancers and suppressing adaptive immune responses in vivo.
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