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Nature Immunology  1, 459 - 460 (2000)
doi:10.1038/82698

NKT cells and tumor immunity—a double-edged sword

Mark J. Smyth1 & Dale I. Godfrey2

1  Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, Locked Bag 1, A'Beckett St, 8006, Australia.

2  Department of Pathology and Immunology, Monash Medical School, Commercial Road, Prahran, Australia.
m.smyth@pmci.unimelb.edu.au

NKT cells can rapidly produce a diversity of immunoregulatory cytokines; does this make these cells aggressors or suppressors? New experiments now reveal their immunosuppressive function in tumor control and reiterate their pivotal position.

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