Nature Immunology
1, 372 - 374 (2000)
doi:10.1038/80808
Signaling for cytotoxicityBice Perussia
Kimmel Cancer Center, Jefferson Medical College, Department
of Microbiology and Immunology, BLSB 750, 233 S. 10th Street,
Philadelphia, PA 19107, USA.
bperussia@hendrix.jci.tju.edu
Once natural killer cells identify their targets they engage their
lysis machinery. Spontaneous, unlike antibody-dependent, cytotoxicity predominantly
uses a Ras-independent pathway to accomplish this activation.
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