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Nature Immunology  1, 367 - 368 (2000)
doi:10.1038/80799

Cytokines, virokines and the evolution of immunity

Steven K. Dower

University Division of Genomic Medicine, Royal Hallamshire Hospital, Sheffield S10 2JF, UK. s.dower@sher.ac.uk

In a new twist, the cytokine IL-10, if present when leukocytes are activated, can disconnect chemokine receptors from signaling for cell migration. The receptors act as a "sink" for soaking up chemokines, thus providing the perfect decoy.

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Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
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