Nature Immunology
1, 342 - 347 (2000)
doi:10.1038/79801
Role of Drosophila IKK in a Toll-independent antibacterial
immune responseSophie Rutschmann1, Alain C. Jung1, Rui Zhou2, Neal Silverman2, Jules A. Hoffmann1
& Dominique Ferrandon11
Institut de Biologie Moléculaire et Cellulaire,
UPR 9022 du CNRS, 15, rue R. Descartes, F67084
Strasbourg Cedex, France. 2
Department of Molecular and Cellular Biology, Harvard
University, Cambridge, MA 02138,
USA.
Correspondence should be addressed to Dominique Ferrandon d.ferrandon@ibmc.u-strasbg.frWe have generated, by ethylmethane sulfonate mutagenesis, loss-of-function
mutants in the Drosophila homolog of the mammalian I- B kinase
(IKK) complex component IKK (also called NEMO). Our data show that Drosophila IKK is required for the Relish-dependent immune induction
of the genes encoding antibacterial peptides and for resistance to infections
by Escherichia coli. However, it is not required for the Toll-DIF−dependent
antifungal host defense. The results indicate distinct control mechanisms
of the Rel-like transactivators DIF and Relish in the Drosophila innate
immune response and show that Drosophila Toll does not signal through
a IKK-dependent signaling complex. Thus, in contrast to the vertebrate
inflammatory response, IKK is required for the activation of only one
immune signaling pathway in Drosophila.
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