Nature Immunology
1, 245 - 251 (2000)
doi:10.1038/79792
Natural killer cells determine the outcome of B cell−mediated autoimmunityFu-Dong Shi1, 5, 6, Hua-Bing Wang2, 5, Hulun Li2, 5, Seokmann Hong3, Masaru Taniguchi4, Hans Link2, Luc Van Kaer3
& Hans-Gustaf Ljunggren11
Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden. 2
Division of Neurology, Huddinge University Hospital, Karolinska Institutet, S-141 86 Stockholm, Sweden. 3
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. 4
Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inobana, Chuo-ku, Chiba, Japan 260. 5
These authors contributed equally to this work. 6
Present address: Department of Immunology, IMM-23, The Scripps Research Institute, 10555 North Torrey Pines Road, La Jolla, CA 92037, USA.
Correspondence should be addressed to Hans-Gustaf Ljunggren hans-gustaf.ljunggren@mtc.ki.seNatural killer (NK) cells can affect the outcome of adaptive immune responses. NK cells, but not NK1.1+ T cells, were found to participate in the development of myasthenia gravis (a T cell−dependent, B cell− and antibody-mediated autoimmune disease) in C57BL/6 mice. The requirement for NK cells was reflected by the lack of a type 1 helper T cell response and antibodies to the acetylcholine receptor in both NK1.1+ cell−depleted and NK cell−deficient IL-18-/- mice. These findings establish a previously unrecognized link between NK cells and autoreactive T and B cells.
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