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Pathogenesis deals with the multifactorial, complex encounters between host and pathogen. Ever-increasing experimental data have revealed many new and unexpected details of the highly sophisticated strategies used by both host immune cells and microbes as they try to subvert or evade each other. With help from many experts in the fields of immunology, microbiology, virology, genetics and biochemistry we provide an annotated list of papers that document seminal contributions to our understanding of pathogenesis. We gratefully acknowledge the following individuals for their help in selecting these landmark classic papers: Bruce Beutler, Ruslan Medzhitov, Emil Unanue, Alain Fischer, Michael Lederman, Joyoti Basu, Ann Hill, Isabella Coppens, Warner Greene, John Harty, Caetano Reis e Sousa, Hidde Ploegh, Frank Chisari, Denise Monack and Stefan H.E. Kaufmann.


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