Classics
Leukocyte trafficking
Report on the discovery of L-selectin.
A cell-surface molecule involved in organ-specific homing of lymphocytes.
Gallatin, W., Weissman, I. & Butcher, E. Nature 304 , 30-34 (1983).PDF
Paper reporting the discovery of the adhesion molecule LFA-1.
Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.
Sanchez-Madrid, F., Krensky, A.M., Ware, C.F., Robbins, E., Strominger, J.L., Burakoff, S.J. & Springer, T.A. Proc. Natl. Acad. Sci. USA 79 , 7489-7493 (1982).Pubmed
Classic paper presenting the first in vitro experimental evidence of the sequential involvement of selectins, chemoattractants and integrins in the leukocyte recruitment cascade.
Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins.
Lawrence, M.B. & Springer, T.A. Cell 65 , 859-873 (1991).Pubmed
First experimental demonstrations that selectins are involved in rolling of leukocytes on endothelium in vivo .
Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte Β2 integrins in vivo .
von Andrian, U.H., Chambers, J.D., McEvoy, L.M., Bargatze, R.F., Arfors, K.E. & Butcher, E.C. Proc. Natl. Acad. Sci. USA 88 , 7538-7542 (1991).Pubmed
Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo .
Ley, K., Gaehtgens, P., Fennie, C., Singer, M.S., Lasky, L.A. & Rosen, S.D. Blood 77 , 2553-2555 (1991).Pubmed
The original in vitro leukocyte-endothelial adhesion assay.
The adhesive interaction between polymorphonuclear leukocytes and endothelial cells in vitro .
Hoover, R.L., Briggs, R.T. & Karnovsky, M.J. Cell 14 , 423-428 (1978).Pubmed
First assay for lymphocyte adhesion in the presence of sheer stress.
Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinities of recirculating lymphocytes for high-endothelial venules.
Stamper, H.B. & Woodruff, J.J. J. Exp. Med. 144 , 828-833 (1976).Pubmed
A critical advance in understanding inflammation was data showing that leukocytes must adhere to microvascular endothelial cells to cause tissue damage in response to inflammatory stimuli. These three papers established formal proof for this idea.
Increase in vascular permeability induced by leukotriene B4 and the role of polymorphonuclear leukocytes.
Bjork, J., Hedqvist, P. & Arfors, K.E. Inflammation 6 , 189-200 (1982).Pubmed
A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo .
Arfors, K.E. et al . Blood 69 , 338-340 (1987).Pubmed
Role of neutrophils in ischemia-reperfusion-induced microvascular injury.
Hernandez, L.A. et al . Am. J. Physiol. 253 , H669-H703 (1987).Pubmed
Classic original report demonstrating activation of endothelial cells and vascular permeability changes at microscopic and cellular levels.
The delayed and prolonged vascular leakage in inflammation. I. Topography of the leaking vessels after thermal injury.
Cotran, R.S. & Majno, G. Am. J. Pathol. 45 , 261-281 (1964).Pubmed
