Focus on Dampening Inflammation


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Cell-mediated suppression

Early data showing that immunity can be actively dampened by suppressor cells.

Infectious immunological tolerance.

Gershon, R.K. & Kondo, K.

Immunology 21, 903-914 (1971).

Pubmed

Seminal paper demonstrating that CD25⁺ T cells inhibit autoimmune responses, documenting the important function of these cells in attenuating immune responses.

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M.

J. Immunol. 155, 1151-1164 (1995).

Pubmed

Demonstration of CTLA-4 as a negative regulator.

CTLA-4 can function as a negative regulator of T cell activation.

Walunas, T.L., Lenschow, D.J., Bakker, C.Y., Linsley, P.S., Freeman, G.J., Green, J.M., Thompson, C.B. & Bluestone, J.A.

Immunology 1, 405-413 (1994).

Pubmed

Secreted interleukin 10 negatively controls regulatory activity in vivo.

Interleukin-10-deficient mice develop chronic enterocolitis.

Kühn, R., Löhler, J., Rennick, D., Rajewsky, K. & Müller, W.

Cell 75, 263-274 (1993).

Pubmed

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