Reports identifying previously unknown lipoxygenase pathway products that were later recognized as the leukotrienes and, in particular, leukotriene B4.
Transformation of arachidonic acid and homo-γ-linolenic acid by rabbit polymorphonuclear leukocytes.
Papers providing the first mechanistic insights into how glucocorticoids modulate proinflammatory cellular signaling pathways, such as by interacting with transcription factors.
Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer.
Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.
Lipid mediators, such as lipoxins, are critical for resolving inflammation. For example, lipoxins mediate downmodulation of neutrophil extravasation. These papers demonstrate negative feedback of the inflammatory response, which is required for platelets to make lipoxins.
Transcellular conversion of endogenous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions.
Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.
Paper demonstrating the presence of biochemical pathways that are actively generated during the resolution phase of acute inflammation (the resolvins).
Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter pro-inflammation signals.
