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Dampening Inflammation
Contents Editorial Overview Reviews
Research Highlights NPG Library Classics Feedback
 Classics
 Anaphylaxis

Experiments in this study demonstrated the importance of chemical mediators in regulating vascular permeability.

Studies on inflammation. I. The effect of histamine and serotonin on vascular permeability: an electron microscopic study.
Majno, G. & Palade, G.E.
Pubmed

An original report on the idea of the release of chemical mediators.

The vasodilator action of histamine and of some other substances.
Dale, H.H. & Richards, A.N.

Original characterization of slow-reacting substance of anaphylaxis.

Occurrence of an unidentified substance during anaphylactic shock in cavy lung.
Brocklehurst, W.E.
Pubmed

A negative regulator that dampens mast cell activation in anaphylaxis.

Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice.
Daheshia, M., Friend, D.S., Grusby, M.J., Austen K.F. & Katz, H.R.
Pubmed

Description of the precursor function of arachidonic acid in the formation of SRS-A (slow-reacting substance of anaphylaxis), which was later identified as leukotrienes C4, D4 and E4.

Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cells.
Jakshcik, B.A., Falkenhein, S. & Parker, C.W.
Pubmed
 
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Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
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