Excessive T cell activation affects behavior

Latest Research

  • Review |

    Lambris and colleagues discuss new and previously unanticipated functions of complement and how these affect immunity and disease pathogenesis.

    • George Hajishengallis
    • , Edimara S Reis
    • , Dimitrios C Mastellos
    • , Daniel Ricklin
    •  & John D Lambris
  • Article |

    The tumor microenvironment represents a stressful cellular environment. Zou and colleagues show that Treg cells in tumors have heightened sensitivity to apoptosis, but unexpectedly this increases their suppressive potency.

    • Tomasz Maj
    • , Wei Wang
    • , Joel Crespo
    • , Hongjuan Zhang
    • , Weimin Wang
    • , Shuang Wei
    • , Lili Zhao
    • , Linda Vatan
    • , Irene Shao
    • , Wojciech Szeliga
    • , Costas Lyssiotis
    • , J Rebecca Liu
    • , Ilona Kryczek
    •  & Weiping Zou
  • Article |

    The polarization of leukocytes toward chemoattractants is essential for their directed migration. Chen and colleagues show that the phosphoinositide-transfer protein TIPE2 functions as a coordinator of leukocyte polarity.

    • Svetlana A Fayngerts
    • , Zhaojun Wang
    • , Ali Zamani
    • , Honghong Sun
    • , Amanda E Boggs
    • , Thomas P Porturas
    • , Weidong Xie
    • , Mei Lin
    • , Terry Cathopoulis
    • , Jason R Goldsmith
    • , Anastassios Vourekas
    •  & Youhai H Chen
  • Article |

    Fagarasan and colleagues show that excessive activation of T cells in mice deficient in the inhibitory receptor PD-1 causes a systemic decrease in tryptophan and tyrosine, which leads to deficiency in serotonin and dopamine in the brain and behavioral changes.

    • Michio Miyajima
    • , Baihao Zhang
    • , Yuki Sugiura
    • , Kazuhiro Sonomura
    • , Matteo M Guerrini
    • , Yumi Tsutsui
    • , Mikako Maruya
    • , Alexis Vogelzang
    • , Kenji Chamoto
    • , Kurara Honda
    • , Takatoshi Hikida
    • , Satomi Ito
    • , Hongyan Qin
    • , Rikako Sanuki
    • , Keiichiro Suzuki
    • , Takahisa Furukawa
    • , Yasushi Ishihama
    • , Fumihiko Matsuda
    • , Makoto Suematsu
    • , Tasuku Honjo
    •  & Sidonia Fagarasan
  • Perspective |

    Recent decades have seen an alarming rise in the incidence of autoimmune disease. In a Perspective, Matarese and colleagues discuss the evidence showing that changes in diet and metabolic workload can account for, at least in part, rises in the frequency of autoimmune disease.

    • Veronica De Rosa
    • , Antonio La Cava
    •  & Giuseppe Matarese
  • Article |

    Gillet and colleagues find that infection with a gammaherpesvirus confers strong and lasting protection against airway allergy through the replacement of lung-resident alveolar macrophages with recruited regulatory monocytes of bone marrow origin.

    • Bénédicte Machiels
    • , Mickael Dourcy
    • , Xue Xiao
    • , Justine Javaux
    • , Claire Mesnil
    • , Catherine Sabatel
    • , Daniel Desmecht
    • , François Lallemand
    • , Philippe Martinive
    • , Hamida Hammad
    • , Martin Guilliams
    • , Benjamin Dewals
    • , Alain Vanderplasschen
    • , Bart N Lambrecht
    • , Fabrice Bureau
    •  & Laurent Gillet

News & Comment

  • News and Views |

    Adenosine produced by apoptotic regulatory T cells (Treg cells) has a more important immunosuppressive role in the tumor microenvironment than that of live Treg cells. This discovery raises the possibility of novel strategies for cancer immunotherapy.

    • Yosuke Togashi
    •  & Hiroyoshi Nishikawa
  • News and Views |

    Abolishing signals mediated by the inhibitory receptor PD-1 results in a systemic decrease in tryptophan and tyrosine, which leads to a striking deficiency in the neurotransmitters serotonin and dopamine in the brain and anxiety-like behavior and exacerbated fear.

    • Laura Strauss
    • , Nikolaos Patsoukis
    •  & Vassiliki A Boussiotis
  • News and Views |

    Replacement of resident alveolar macrophages by monocyte-derived macrophages after herpesvirus infection protects against asthma.

    • Bérengère de Laval
    •  & Michael H Sieweke

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