Focus on Autoimmune disease

Latest Research

  • Article |

    Lymphocytes interpret antigenic signals into a functional response. Richard et al. demonstrate that the overall qualitative response by CTLs is independent of TCR ligand strength; instead, ligands determine the rate and uniformity at which CTLs respond.

    • Arianne C. Richard
    • , Aaron T. L. Lun
    • , Winnie W. Y. Lau
    • , Berthold Göttgens
    • , John C. Marioni
    •  & Gillian M. Griffiths
  • Article |

    Evidence of protective and homeostatic roles for IgE is relatively limited. Strid and colleagues demonstrate that γδ T cells induce switching to IgE that provides protection against experimentally induced epithelial cancer.

    • Greg Crawford
    • , Mark David Hayes
    • , Rocio Castro Seoane
    • , Sophie Ward
    • , Tim Dalessandri
    • , Chester Lai
    • , Eugene Healy
    • , David Kipling
    • , Charlotte Proby
    • , Colin Moyes
    • , Kile Green
    • , Katie Best
    • , Muzlifah Haniffa
    • , Marina Botto
    • , Deborah Dunn-Walters
    •  & Jessica Strid
  • Resource |

    Soumelis and colleagues use RNA-based sequencing to define the transcriptional signatures of DC subsets and monocytes-macrophages in human primary breast cancer.

    • Paula Michea
    • , Floriane Noël
    • , Eve Zakine
    • , Urszula Czerwinska
    • , Philémon Sirven
    • , Omar Abouzid
    • , Christel Goudot
    • , Alix Scholer-Dahirel
    • , Anne Vincent-Salomon
    • , Fabien Reyal
    • , Sebastian Amigorena
    • , Maude Guillot-Delost
    • , Elodie Segura
    •  & Vassili Soumelis
  • Article |

    TCRs are often thought to be pre-clustered before T cell activation. Rossboth et al. use super-resolution microscopy and statistical image analysis to demonstrate that TCRs are in fact randomly distributed on resting T cells.

    • Benedikt Rossboth
    • , Andreas M. Arnold
    • , Haisen Ta
    • , René Platzer
    • , Florian Kellner
    • , Johannes B. Huppa
    • , Mario Brameshuber
    • , Florian Baumgart
    •  & Gerhard J. Schütz
  • Article |

    B cells need at least two signals to terminally differentiate into antibody-secreting cells. Pierce and colleagues show that persistent exposure to antigen in the absence of T cell help or ‘pathogen pattern motifs’ leads to B cell death via a calcium-dependent ‘metabolic timer’.

    • Munir Akkaya
    • , Javier Traba
    • , Alexander S. Roesler
    • , Pietro Miozzo
    • , Billur Akkaya
    • , Brandon P. Theall
    • , Haewon Sohn
    • , Mirna Pena
    • , Margery Smelkinson
    • , Juraj Kabat
    • , Eric Dahlstrom
    • , David W. Dorward
    • , Jeff Skinner
    • , Michael N. Sack
    •  & Susan K. Pierce
  • Article |

    Foxo proteins are required for maintaining T cell quiescence. Turka and colleagues use a constitutively active Foxo1 in Treg cells to show that its downregulation is essential for maintaining their fitness in a competitive environment.

    • Ryan H. Newton
    • , Sharad Shrestha
    • , Jenna M. Sullivan
    • , Kathleen B. Yates
    • , Ewoud B. Compeer
    • , Noga Ron-Harel
    • , Bruce R. Blazar
    • , Steven J. Bensinger
    • , W. Nicholas Haining
    • , Michael L. Dustin
    • , Daniel J. Campbell
    • , Hongbo Chi
    •  & Laurence A. Turka

News & Comment

  • News & Views |

    T cell activation is ‘digital’: exhaustive single-cell analysis shows that only the proportion of cells that cross the activation threshold is reduced when the affinity of the TCR for its ligand is reduced.

    • Renu Balyan
    • , Joanna Brzostek
    •  & Nicholas R. J. Gascoigne
  • News & Views |

    In response to epithelial DNA damage, tissue-resident γδ T cells initiate and shape a tumor-protective IgE response that requires CD4+ T cells and immune effector cells expressing the high-affinity IgE receptor FcεRI.

    • J. Michael McGraw
    •  & Wendy L. Havran
  • News & Views |

    What keeps memory T cells functionally silent in the absence of infection is unclear. New data reveal the existence of a deterministic halt in the protein-synthesis machinery of memory T cells and expose the discriminatory functions of a family of RNA-binding proteins.

    • Dimitris L. Kontoyiannis
  • News & Views |

    Co-stimulatory second signals delivered through TLRs or CD40 rescue antigen-stimulated B cells from metabolic dysfunction and apoptosis. This identifies a critical time-limited window during which B cells integrate sequential signals to successfully initiate humoral immunity.

    • Tri Giang Phan
    •  & Stuart G. Tangye
  • News & Views |

    Plasmacytoid dendritic cells (pDCs) are type I interferon–producing cells with antigen-presenting potential. pDC populations are composed of transcriptionally and functionally heterogeneous cellular subsets with distinct hematopoietic precursor origin.

    • Markus G. Manz

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