Variability of human immunity

Latest Research

  • Article |

    The presentation of antigen by germinal-center B cells to follicular T cells engenders the process of antibody affinity maturation and humoral memory. Pierce and colleagues show that TLR9 signaling in B cells antagonizes B cell–mediated antigen presentation, which leads to the enhanced generation of short-lived plasma cells and the production of lower-affinity antibodies.

    • Munir Akkaya
    • , Billur Akkaya
    • , Ann S. Kim
    • , Pietro Miozzo
    • , Haewon Sohn
    • , Mirna Pena
    • , Alexander S. Roesler
    • , Brandon P. Theall
    • , Travis Henke
    • , Juraj Kabat
    • , Jinghua Lu
    • , David W. Dorward
    • , Eric Dahlstrom
    • , Jeff Skinner
    • , Louis H. Miller
    •  & Susan K. Pierce
  • Resource |

    Both environmental factors and genetic factors influence human immunity. Albert and colleagues leverage data from the Milieu Intérieur Consortium to comprehensively describe the effects of lifestyle, environment and genetics on human innate and adaptive immunity.

    • Etienne Patin
    • , Milena Hasan
    • , Jacob Bergstedt
    • , Vincent Rouilly
    • , Valentina Libri
    • , Alejandra Urrutia
    • , Cécile Alanio
    • , Petar Scepanovic
    • , Christian Hammer
    • , Friederike Jönsson
    • , Benoît Beitz
    • , Hélène Quach
    • , Yoong Wearn Lim
    • , Julie Hunkapiller
    • , Magge Zepeda
    • , Cherie Green
    • , Barbara Piasecka
    • , Claire Leloup
    • , Lars Rogge
    • , François Huetz
    • , Isabelle Peguillet
    • , Olivier Lantz
    • , Magnus Fontes
    • , James P. Santo
    • , Stéphanie Thomas
    • , Jacques Fellay
    • , Darragh Duffy
    • , Lluís Quintana-Murci
    •  & Matthew L. Albert
  • Article |

    Wang and colleagues show that the transcription factor Hoxb5, which is expressed in uncommitted hematopoietic progenitor cells but is absent from committed B cells and T cells, can reprogram pro-pre-B cells into functional early T cell lineage progenitors.

    • Mengyun Zhang
    • , Yong Dong
    • , Fangxiao Hu
    • , Dan Yang
    • , Qianhao Zhao
    • , Cui Lv
    • , Ying Wang
    • , Chengxiang Xia
    • , Qitong Weng
    • , Xiaofei Liu
    • , Chen Li
    • , Peiqing Zhou
    • , Tongjie Wang
    • , Yuxian Guan
    • , Rongqun Guo
    • , Lijuan Liu
    • , Yang Geng
    • , Hongling Wu
    • , Juan Du
    • , Zheng Hu
    • , Sheng Xu
    • , Jiekai Chen
    • , Aibin He
    • , Bing Liu
    • , Demin Wang
    • , Yong-Guang Yang
    •  & Jinyong Wang
  • Review Article |

    Primary liver cancer, of which hepatocellular carcinoma is the most common form, is the second leading cause of cancer-related death. Heikenwalder and colleagues review the important inflammatory component underlying hepatocellular carcinoma and consider potential directions for therapy.

    • Marc Ringelhan
    • , Dominik Pfister
    • , Tracy O’Connor
    • , Eli Pikarsky
    •  & Mathias Heikenwalder

News & Comment

  • Correspondence |

    • Ana Mafalda Santos
    • , Aleks Ponjavic
    • , Marco Fritzsche
    • , Ricardo A. Fernandes
    • , Jorge Bernardino de la Serna
    • , Martin J. Wilcock
    • , Falk Schneider
    • , Iztok Urbančič
    • , James McColl
    • , Consuelo Anzilotti
    • , Kristina A. Ganzinger
    • , Meike Aßmann
    • , David Depoil
    • , Richard J. Cornall
    • , Michael L. Dustin
    • , David Klenerman
    • , Simon J. Davis
    • , Christian Eggeling
    •  & Steven F. Lee
  • News & Views |

    Tumor cells downregulate type I interferon responses through their delivery of immunomodulatory exosomes, which has implications for antiviral suppression in people with cancer.

    • Akinori Takaoka

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