Nature Immunology - Current issue : November 2009 - Vol 10 No 11
Latest highlights
Article of the month
Maintaining Foxp3 expression
Article by MuraiInterleukin 10–deficient mice develop spontaneous colitis. Kronenberg and colleagues find that interleukin 10 released by myeloid cells in the intestine is needed to maintain expression of the transcription factor Foxp3 in regulatory T cells.
See also:
News & Views by Unutmaz & PulendranAdvance online publication
Nod proteins in autophagy
Article by TravassosAutophagy facilitates host defense against invading bacteria. Philpott and colleagues show that Nod1 and Nod2 link pathogen sensing to autophagy by recruiting the autophagy protein AGT16L1 to the site of pathogen entry.
Advance online publication
Generating mature antibodies
Article by RandallHigh-affinity and isotype-switched antibodies arise from germinal center reactions. Goodnow and colleagues identify the Rho guanine nucleotide–exchange factor DOCK8 as being essential for sustained B cell immune synapse formation in germinal centers and mature antibody responses.
Advance online publication
Ubiquitinylation governs TRAF3
Article by TsengTLR4 signals via MyD88 and TRIF to activate proinflammatory cytokine and type I interferon responses. Karin and colleagues show that different ubiquitination of TRAF3 via K48 or K63 dictates the ensuing immune response.
Advance online publication
Surviving with calcium
Article by JhaT cell activation triggers large calcium fluxes. Flavell and colleagues show tonic calcium signaling via Cav1.4-β3 channels are needed for the survival and homeostasis of naive CD8+ T cells.
Announcement
The Fondation IPSEN, Nature Immunology and Nature Reviews Molecular Cell Biology are pleased to announce an Emergence & Convergence mini-symposium:
Epigenetic Dynamics in the Immune System
February 19, 2010, The St. Anthony, San Antonio, TX, USA
For more information and to register, visit http://www.nature.com/natureconferences
/eandc/epigimm/index.html.
