Nature Immunology - Current issue : July 2009 - Vol 10 No 7
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Article of the month
Regulatory T cells (Treg cells) are necessary for maintaining peripheral tolerance. Chi and colleagues show that the receptor S1P1 negatively regulates thymic Treg cells production and blocks Treg cells cell activity via an Akt-mTor pathway.
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News & Views by Ohkura & SakaguchiAdvance online publication
Helper T cells become polarized to effect a 'division of labor'. Sallusto and Spits and colleagues identify a new subset of skin-homing helper T cells, TH-22 cells, that secrete interleukin 22.
Current issue
Basophils act as effector cells in immunoglobulin E–mediated hypersensitivity responses. Artis, Nakanishi and Medzhitov and their colleagues report that basophils present antigen and induce T helper type 2 responses to helminths, allergens and immunoglobulin E immune complexes.
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News & Views by WynnCurrent issue
Regulating TLR signaling
Article by WangE3 ubiquitin ligases are critical for innate and adaptive immunity. Cao and colleagues show that the E3 ubiquitin ligase Nrdp inhibits the production of proinflammatory cytokines while promoting the release of interferon-β in Toll-like receptor-triggered macrophages.
Current issue
DAP12 drives M-CSF signals
Article by OteroMacrophage colony stimulating factor induces macrophage proliferation. Colonna and colleagues now show macrophage proliferation and survival involves DAP12-dependent β-catenin stabilization.
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News & Views by McVicar & TrinchieriFocus
Nature Immunology presents a focus on the complex interplay among signaling pathways operative in immune cells. The focus contains a specially commissioned overview, three review articles and two perspectives. Also included are highlights of recent research findings and several short comments—written by experts—providing in-depth insight into specific signal cross-talk points.
